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SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Curcumin Phytosome(Turmeric Rhizome Extract (curcuma longa)/Phosphatidyl Choline Complex) (Meriva® Turmeric Phytosome)(Standardized to min. 18% Curcuminoids - 90 mg)
500 mg
**
Top Medical Research Studies
9
Curcumin inhibits platelet activation
Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.
Aim at Alzheimer’s-related blood clots
We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
Read More
9
Curcumin enhances blood clot resolution
Curcumin promotes venous thrombi resolve process in a mouse deep venous thrombosis model via regulating miR-499.
Focuses on blood clot therapy
We explored the potential benefits of curcumin, the active compound in turmeric, in helping to resolve blood clots, particularly in cases of deep venous thrombosis (DVT). The study investigated whether curcumin could support the natural process of venous thrombi resolution, a crucial aspect of managing DVT.
Using various laboratory techniques, including immunofluorescence staining and microarray analysis, we assessed how curcumin affects angiogenesis—the creation of new blood vessels—that is essential for thrombus resolution. We found that curcumin significantly enhances the therapeutic angiogenesis process, aiding in the recovery of affected tissues.
Interestingly, we also observed that curcumin led to a decrease in the expression of a specific microRNA, miR-499, which is connected to the regulation of a protein known as PTEN. This suggests a mechanism whereby curcumin promotes healing by modulating important signaling pathways involved in blood vessel formation and repair.
Overall, our findings indicate that curcumin could be an effective natural treatment for enhancing the body's ability to resolve blood clots through promoting therapeutic angiogenesis. This discovery opens new avenues for DVT treatment strategies that could be more effective than traditional methods.
Using various laboratory techniques, including immunofluorescence staining and microarray analysis, we assessed how curcumin affects angiogenesis—the creation of new blood vessels—that is essential for thrombus resolution. We found that curcumin significantly enhances the therapeutic angiogenesis process, aiding in the recovery of affected tissues.
Interestingly, we also observed that curcumin led to a decrease in the expression of a specific microRNA, miR-499, which is connected to the regulation of a protein known as PTEN. This suggests a mechanism whereby curcumin promotes healing by modulating important signaling pathways involved in blood vessel formation and repair.
Overall, our findings indicate that curcumin could be an effective natural treatment for enhancing the body's ability to resolve blood clots through promoting therapeutic angiogenesis. This discovery opens new avenues for DVT treatment strategies that could be more effective than traditional methods.
Read More
9
Tetrahydrocurcumin reduces blood clotting
Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth.
Study highlights turmeric's effectiveness.
We explored the effects of tetrahydrocurcumin (THC), a major metabolite of turmeric's active compound, curcumin, on blood clot formation and platelet behavior. Our focus was on how THC influences platelet granule secretion and thrombus growth, crucial factors in atherothrombosis.
In laboratory settings, we observed that THC significantly reduced the release of substances that promote clot formation, such as CD62P and CD63, as well as platelet factor 4 and adenosine triphosphate. The mechanism behind this involves THC downregulating specific pathways that trigger the activation of enzymes involved in thromboxane A2 (TxA) production—a key player in platelet activation and clotting.
When tested in mice with induced thrombosis, THC showed potent inhibitory effects on clot formation without increasing bleeding time, suggesting it could be a safer alternative to other treatments. Interestingly, we found that THC worked effectively alongside aspirin, a common blood thinner, without diminishing its effects.
Overall, our findings suggest that tetrahydrocurcumin has promising potential as a cardioprotective agent, particularly in managing blood clot risks.
In laboratory settings, we observed that THC significantly reduced the release of substances that promote clot formation, such as CD62P and CD63, as well as platelet factor 4 and adenosine triphosphate. The mechanism behind this involves THC downregulating specific pathways that trigger the activation of enzymes involved in thromboxane A2 (TxA) production—a key player in platelet activation and clotting.
When tested in mice with induced thrombosis, THC showed potent inhibitory effects on clot formation without increasing bleeding time, suggesting it could be a safer alternative to other treatments. Interestingly, we found that THC worked effectively alongside aspirin, a common blood thinner, without diminishing its effects.
Overall, our findings suggest that tetrahydrocurcumin has promising potential as a cardioprotective agent, particularly in managing blood clot risks.
Read More
Most Useful Reviews
8.8
Liver benefits
"The PC has shown benefits for the liver, intestines, and lungs. Curcumin Phytosome, which is a curcumin molecule attached to PC (PhosphatidylCholine), is excellently absorbed. It transports curcumin effectively across the intestinal lining into the blood, making it over 29 times better absorbed than curcumin alone."
Read More
8.8
Improves joint mobility
"Curcumin phytosome, derived from enhanced turmeric root extract, has a tonic and antioxidant effect. It improves blood composition and reduces viscosity, lowering the risk of blood clots. My mother, who has diabetes, finds it suitable. While I cannot assess its effect immediately, it has improved her joint mobility."
Read More
9.3
Effective anti-inflammatory
"Curcumin is a fantastic supplement, an excellent anti-inflammatory that promotes blood thinning."
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
9
Curcumin inhibits platelet activation
Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.
Aim at Alzheimer’s-related blood clots
We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
Read More
9
Tetrahydrocurcumin reduces blood clotting
Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth.
Study highlights turmeric's effectiveness.
We explored the effects of tetrahydrocurcumin (THC), a major metabolite of turmeric's active compound, curcumin, on blood clot formation and platelet behavior. Our focus was on how THC influences platelet granule secretion and thrombus growth, crucial factors in atherothrombosis.
In laboratory settings, we observed that THC significantly reduced the release of substances that promote clot formation, such as CD62P and CD63, as well as platelet factor 4 and adenosine triphosphate. The mechanism behind this involves THC downregulating specific pathways that trigger the activation of enzymes involved in thromboxane A2 (TxA) production—a key player in platelet activation and clotting.
When tested in mice with induced thrombosis, THC showed potent inhibitory effects on clot formation without increasing bleeding time, suggesting it could be a safer alternative to other treatments. Interestingly, we found that THC worked effectively alongside aspirin, a common blood thinner, without diminishing its effects.
Overall, our findings suggest that tetrahydrocurcumin has promising potential as a cardioprotective agent, particularly in managing blood clot risks.
In laboratory settings, we observed that THC significantly reduced the release of substances that promote clot formation, such as CD62P and CD63, as well as platelet factor 4 and adenosine triphosphate. The mechanism behind this involves THC downregulating specific pathways that trigger the activation of enzymes involved in thromboxane A2 (TxA) production—a key player in platelet activation and clotting.
When tested in mice with induced thrombosis, THC showed potent inhibitory effects on clot formation without increasing bleeding time, suggesting it could be a safer alternative to other treatments. Interestingly, we found that THC worked effectively alongside aspirin, a common blood thinner, without diminishing its effects.
Overall, our findings suggest that tetrahydrocurcumin has promising potential as a cardioprotective agent, particularly in managing blood clot risks.
Read More
9
Curcumin enhances blood clot resolution
Curcumin promotes venous thrombi resolve process in a mouse deep venous thrombosis model via regulating miR-499.
Focuses on blood clot therapy
We explored the potential benefits of curcumin, the active compound in turmeric, in helping to resolve blood clots, particularly in cases of deep venous thrombosis (DVT). The study investigated whether curcumin could support the natural process of venous thrombi resolution, a crucial aspect of managing DVT.
Using various laboratory techniques, including immunofluorescence staining and microarray analysis, we assessed how curcumin affects angiogenesis—the creation of new blood vessels—that is essential for thrombus resolution. We found that curcumin significantly enhances the therapeutic angiogenesis process, aiding in the recovery of affected tissues.
Interestingly, we also observed that curcumin led to a decrease in the expression of a specific microRNA, miR-499, which is connected to the regulation of a protein known as PTEN. This suggests a mechanism whereby curcumin promotes healing by modulating important signaling pathways involved in blood vessel formation and repair.
Overall, our findings indicate that curcumin could be an effective natural treatment for enhancing the body's ability to resolve blood clots through promoting therapeutic angiogenesis. This discovery opens new avenues for DVT treatment strategies that could be more effective than traditional methods.
Using various laboratory techniques, including immunofluorescence staining and microarray analysis, we assessed how curcumin affects angiogenesis—the creation of new blood vessels—that is essential for thrombus resolution. We found that curcumin significantly enhances the therapeutic angiogenesis process, aiding in the recovery of affected tissues.
Interestingly, we also observed that curcumin led to a decrease in the expression of a specific microRNA, miR-499, which is connected to the regulation of a protein known as PTEN. This suggests a mechanism whereby curcumin promotes healing by modulating important signaling pathways involved in blood vessel formation and repair.
Overall, our findings indicate that curcumin could be an effective natural treatment for enhancing the body's ability to resolve blood clots through promoting therapeutic angiogenesis. This discovery opens new avenues for DVT treatment strategies that could be more effective than traditional methods.
Read More
8
Curcumin's role in clot prevention
The regulatory role of curcumin on platelet functions.
Moderate relevance to blood clots
We explored how curcumin, the active component found in turmeric, can influence blood clotting. This powerful phytochemical has been traditionally used as a spice and herbal remedy for its various health benefits, especially in Asian cultures. Recent studies highlighted curcumin's potential effects on platelet function, hinting at its promise in treating conditions like thrombosis and inflammatory diseases.
Our investigation shows that curcumin might help improve platelet dysfunction, a condition that could lead to cardiovascular disease. Through several studies, we've observed that curcumin demonstrates antiplatelet activity, meaning it can help prevent excessive clotting. As we sift through the evidence, it becomes clear that curcumin serves as a fascinating candidate for addressing issues related to blood clotting.
While the data is promising, it is essential to acknowledge that more comprehensive and controlled trials are necessary to confirm these findings fully. However, the results we've examined suggest curcumin could be a valuable ally in maintaining healthy platelet function and potentially reducing the risk of clots.
Our investigation shows that curcumin might help improve platelet dysfunction, a condition that could lead to cardiovascular disease. Through several studies, we've observed that curcumin demonstrates antiplatelet activity, meaning it can help prevent excessive clotting. As we sift through the evidence, it becomes clear that curcumin serves as a fascinating candidate for addressing issues related to blood clotting.
While the data is promising, it is essential to acknowledge that more comprehensive and controlled trials are necessary to confirm these findings fully. However, the results we've examined suggest curcumin could be a valuable ally in maintaining healthy platelet function and potentially reducing the risk of clots.
Read More
8
Curcumin's role in clotting
Curcumin, hemostasis, thrombosis, and coagulation.
Moderately relevant to blood clotting
The study we reviewed delves into the effectiveness of curcumin, a compound derived from turmeric, on blood clotting processes. It highlights that curcumin is well-known for its safe, non-toxic properties and has been used in various alternative medicine practices.
We discovered that curcumin exhibits several beneficial effects on cardiovascular health, particularly in terms of managing hemostasis and coagulation. The research indicates that curcumin may possess anti-inflammatory and antithrombotic properties, which could positively influence how platelets behave during clot formation.
The findings suggest that curcumin could play a role in the prevention of cardiovascular diseases related to blood clotting. This opens up interesting possibilities for using turmeric as a natural approach to support heart health.
We discovered that curcumin exhibits several beneficial effects on cardiovascular health, particularly in terms of managing hemostasis and coagulation. The research indicates that curcumin may possess anti-inflammatory and antithrombotic properties, which could positively influence how platelets behave during clot formation.
The findings suggest that curcumin could play a role in the prevention of cardiovascular diseases related to blood clotting. This opens up interesting possibilities for using turmeric as a natural approach to support heart health.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Thrombosis prevention
"For information - curcumin is excellent against thrombosis and does not affect blood formula; there is no bleeding from it."
9.3
Effective anti-inflammatory
"Curcumin is a fantastic supplement, an excellent anti-inflammatory that promotes blood thinning."
9
Regulates blood sugar
"This bioavailable form really regulates blood sugar and relieves inflammation in arthritis with prolonged use."
8.8
Liver benefits
"The PC has shown benefits for the liver, intestines, and lungs. Curcumin Phytosome, which is a curcumin molecule attached to PC (PhosphatidylCholine), is excellently absorbed. It transports curcumin effectively across the intestinal lining into the blood, making it over 29 times better absorbed than curcumin alone."
Read More
8.8
Improves joint mobility
"Curcumin phytosome, derived from enhanced turmeric root extract, has a tonic and antioxidant effect. It improves blood composition and reduces viscosity, lowering the risk of blood clots. My mother, who has diabetes, finds it suitable. While I cannot assess its effect immediately, it has improved her joint mobility."
Read More
